A team of UC Davis Health scientists and physicians has identified a cellular connection between diabetes and one of its major complications — blood vessel narrowing that increases risks of several serious health conditions, including heart disease and stroke. For the new study, published in The Journal of Clinical Investigation, the Navedo lab team conducted a series of experiments on the effects of high glucose on cerebral blood vessels and arterial cells that control blood flow. The tests were conducted on a unique genetically modified mouse and two mouse models of diabetes that were developed at UC Davis for studies of cardiovascular health. Several MCIP faculty members participated in this research, including Drs. Madeline Nieves-Cintron, Fernando Santana, Y. Kevin Xiang, and Nipavan Chiamvimonvat.